RNA polymerase inaccuracy underlies SARS-CoV-2 variants and vaccine heterogeneity

Both the SARS-CoV-2 virus and its mRNA vaccines depend on RNA polymerases (RNAP)(1,2); however, these enzymes are inherently error-prone and can introduce variants into the RNA(3). To understand SARS-CoV-2 evolution and vaccine efficacy, it is critical to identify the extent and distribution of erro...

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Detalles Bibliográficos
Autores principales: Bradley, Catherine C., Gordon, Alasdair J.E., Wang, Chen, Cooke, Matthew B., Kohrn, Brendan F., Kennedy, Scott R., Lichtarge, Olivier, Ronca, Shannon E., Herman, Christophe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Journal Experts 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9176646/
https://www.ncbi.nlm.nih.gov/pubmed/35677076
http://dx.doi.org/10.21203/rs.3.rs-1690086/v1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9176646/
https://www.ncbi.nlm.nih.gov/pubmed/35677076
http://dx.doi.org/10.21203/rs.3.rs-1690086/v1

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