Design, synthesis and biological evaluation of novel triazoloquinazolinone and imidazoquinazolinone derivatives as allosteric inhibitors of SHP2 phosphatase

A series of novel triazoloquinolinone and imidazoquinazolinone derivatives were designed and synthesised, and their biological activities against SHP2 protein and melanoma A357 cell line were evaluated in vitro. The results show that some target compounds have moderate to excellent inhibitory activi...

Descripción completa

Detalles Bibliográficos
Autores principales: Ye, Wenjun, Liu, Ye, Ren, Qian, Liao, Tianhui, Chen, Yumei, Chen, Dongmei, Wang, Sisi, Yao, Lihong, Jia, Yihe, Zhao, Chunshen, Zhou, Zhixu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2022
Materias:
Research Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9176666/
https://www.ncbi.nlm.nih.gov/pubmed/35635145
http://dx.doi.org/10.1080/14756366.2022.2078968

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9176666/
https://www.ncbi.nlm.nih.gov/pubmed/35635145
http://dx.doi.org/10.1080/14756366.2022.2078968

Ejemplares similares