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Interaction of letrozole and its degradation products with aromatase: chemometric assessment of kinetics and structure-based binding validation
Letrozole is one of the most prescribed drugs for the treatment of breast cancer in post-menopausal women, and it is endowed with selective peripheral aromatase inhibitory activity. The efficacy of this drug is also a consequence of its long-lasting activity, likely due to its metabolic stability. T...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Taylor & Francis
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9176668/ https://www.ncbi.nlm.nih.gov/pubmed/35635194 http://dx.doi.org/10.1080/14756366.2022.2081845 |