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Sequence dependence of transient Hoogsteen base pairing in DNA

Hoogsteen (HG) base pairing is characterized by a 180° rotation of the purine base with respect to the Watson-Crick-Franklin (WCF) motif. Recently, it has been found that both conformations coexist in a dynamical equilibrium and that several biological functions require HG pairs. This relevance has...

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Detalles Bibliográficos
Autores principales: Pérez de Alba Ortíz, Alberto, Vreede, Jocelyne, Ensing, Bernd
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9177043/
https://www.ncbi.nlm.nih.gov/pubmed/35617357
http://dx.doi.org/10.1371/journal.pcbi.1010113