Genetic and pharmacologic proteasome augmentation ameliorates Alzheimer’s-like pathology in mouse and fly APP overexpression models

The proteasome has key roles in neuronal proteostasis, including the removal of misfolded and oxidized proteins, presynaptic protein turnover, and synaptic efficacy and plasticity. Proteasome dysfunction is a prominent feature of Alzheimer’s disease (AD). We show that prevention of proteasome dysfun...

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Detalles Bibliográficos
Autores principales: Chocron, E. Sandra, Munkácsy, Erin, Kim, Harper S., Karpowicz, Przemyslaw, Jiang, Nisi, Van Skike, Candice E., DeRosa, Nicholas, Banh, Andy Q., Palavicini, Juan P., Wityk, Paweł, Kalinowski, Leszek, Galvan, Veronica, Osmulski, Pawel A., Jankowska, Elzbieta, Gaczynska, Maria, Pickering, Andrew M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2022
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9177073/
https://www.ncbi.nlm.nih.gov/pubmed/35675410
http://dx.doi.org/10.1126/sciadv.abk2252

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9177073/
https://www.ncbi.nlm.nih.gov/pubmed/35675410
http://dx.doi.org/10.1126/sciadv.abk2252

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