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Signaling Downstream of Focal Adhesions Regulates Stiffness-Dependent Differences in the TGF-β1-Mediated Myofibroblast Differentiation of Corneal Keratocytes

Following injury and refractive surgery, corneal wound healing can initiate a protracted fibrotic response that interferes with ocular function. This fibrosis is related, in part, to the myofibroblast differentiation of corneal keratocytes in response to transforming growth factor beta 1 (TGF-β1). P...

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Detalles Bibliográficos
Autores principales: Maruri, Daniel P., Iyer, Krithika S., Schmidtke, David W., Petroll, W. Matthew, Varner, Victor D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9177138/
https://www.ncbi.nlm.nih.gov/pubmed/35693927
http://dx.doi.org/10.3389/fcell.2022.886759