Stereospecific lasofoxifene derivatives reveal the interplay between estrogen receptor alpha stability and antagonistic activity in ESR1 mutant breast cancer cells

Chemical manipulation of estrogen receptor alpha ligand binding domain structural mobility tunes receptor lifetime and influences breast cancer therapeutic activities. Selective estrogen receptor modulators (SERMs) extend estrogen receptor alpha (ERα) cellular lifetime/accumulation. They are antagon...

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Detalles Bibliográficos
Autores principales: Hosfield, David J, Weber, Sandra, Li, Nan-Sheng, Sauvage, Madline, Joiner, Carstyn F, Hancock, Govinda R, Sullivan, Emily A, Ndukwe, Estelle, Han, Ross, Cush, Sydney, Lainé, Muriel, Mader, Sylvie C, Greene, Geoffrey L, Fanning, Sean W
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2022
Materias:
Biochemistry and Chemical Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9177151/
https://www.ncbi.nlm.nih.gov/pubmed/35575456
http://dx.doi.org/10.7554/eLife.72512

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9177151/
https://www.ncbi.nlm.nih.gov/pubmed/35575456
http://dx.doi.org/10.7554/eLife.72512

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