Cargando…
Stereospecific lasofoxifene derivatives reveal the interplay between estrogen receptor alpha stability and antagonistic activity in ESR1 mutant breast cancer cells
Chemical manipulation of estrogen receptor alpha ligand binding domain structural mobility tunes receptor lifetime and influences breast cancer therapeutic activities. Selective estrogen receptor modulators (SERMs) extend estrogen receptor alpha (ERα) cellular lifetime/accumulation. They are antagon...
Autores principales: | Hosfield, David J, Weber, Sandra, Li, Nan-Sheng, Sauvage, Madline, Joiner, Carstyn F, Hancock, Govinda R, Sullivan, Emily A, Ndukwe, Estelle, Han, Ross, Cush, Sydney, Lainé, Muriel, Mader, Sylvie C, Greene, Geoffrey L, Fanning, Sean W |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
eLife Sciences Publications, Ltd
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9177151/ https://www.ncbi.nlm.nih.gov/pubmed/35575456 http://dx.doi.org/10.7554/eLife.72512 |
Ejemplares similares
-
THU546 A Lasofoxifene/Elacestrant Hybrid Antiestrogen Shows Effective Anti-tumoral Activities In Y537S ESR1 Breast Cancer Xenografts
por: Young, Kristen S, et al.
Publicado: (2023) -
Lasofoxifene as a potential treatment for therapy-resistant ER-positive metastatic breast cancer
por: Lainé, Muriel, et al.
Publicado: (2021) -
SUN-006 Lasofoxifene Achieves Potent Anti-Tumor Activity in Hormone-Resistant Breast Tumors by Maintaining High Affinity Binding for Y537S ERα
por: Fanning, Sean, et al.
Publicado: (2019) -
Lasofoxifene for the prevention and treatment of postmenopausal osteoporosis
por: Lewiecki, E Michael
Publicado: (2009) -
Unconventional isoquinoline-based SERMs elicit fulvestrant-like transcriptional programs in ER+ breast cancer cells
por: Hancock, G. R., et al.
Publicado: (2022)