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Efficient aqueous remote loading of peptides in poly(lactic-co-glycolic acid)

Poly(lactic-co-glycolic acid) (PLGA) long-acting release depots are effective for extending the duration of action of peptide drugs. We describe efficient organic-solvent-free remote encapsulation based on the capacity of common uncapped PLGA to bind and absorb into the polymer phase net positively...

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Detalles Bibliográficos
Autores principales: Giles, Morgan B., Hong, Justin K. Y., Liu, Yayuan, Tang, Jie, Li, Tinghui, Beig, Avital, Schwendeman, Anna, Schwendeman, Steven P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9177552/
https://www.ncbi.nlm.nih.gov/pubmed/35676271
http://dx.doi.org/10.1038/s41467-022-30813-7