Structural basis of substrate recognition and translocation by human very long-chain fatty acid transporter ABCD1

Human ABC transporter ABCD1 transports very long-chain fatty acids from cytosol to peroxisome for β-oxidation, dysfunction of which usually causes the X-linked adrenoleukodystrophy (X-ALD). Here, we report three cryogenic electron microscopy structures of ABCD1: the apo-form, substrate- and ATP-boun...

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Detalles Bibliográficos
Autores principales: Chen, Zhi-Peng, Xu, Da, Wang, Liang, Mao, Yao-Xu, Li, Yang, Cheng, Meng-Ting, Zhou, Cong-Zhao, Hou, Wen-Tao, Chen, Yuxing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9177597/
https://www.ncbi.nlm.nih.gov/pubmed/35676282
http://dx.doi.org/10.1038/s41467-022-30974-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9177597/
https://www.ncbi.nlm.nih.gov/pubmed/35676282
http://dx.doi.org/10.1038/s41467-022-30974-5

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