Phosphorylation of SHP2 at Tyr62 Enables Acquired Resistance to SHP2 Allosteric Inhibitors in FLT3-ITD–Driven AML

The protein tyrosine phosphatase SHP2 is crucial for oncogenic transformation of acute myeloid leukemia (AML) cells expressing mutated receptor tyrosine kinases. SHP2 is required for full RAS-ERK activation to promote cell proliferation and survival programs. Allosteric SHP2 inhibitors act by stabil...

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Detalles Bibliográficos
Autores principales: Pfeiffer, Anamarija, Franciosa, Giulia, Locard-Paulet, Marie, Piga, Ilaria, Reckzeh, Kristian, Vemulapalli, Vidyasiri, Blacklow, Stephen C., Theilgaard-Mönch, Kim, Jensen, Lars J., Olsen, Jesper V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for Cancer Research 2022
Materias:
Molecular Cell Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9177641/
https://www.ncbi.nlm.nih.gov/pubmed/35311954
http://dx.doi.org/10.1158/0008-5472.CAN-21-0548

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9177641/
https://www.ncbi.nlm.nih.gov/pubmed/35311954
http://dx.doi.org/10.1158/0008-5472.CAN-21-0548

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