Ascitic fluid shear stress in concert with hepatocyte growth factor drive stemness and chemoresistance of ovarian cancer cells via the c-Met-PI3K/Akt-miR-199a-3p signaling pathway

Overcoming drug resistance is an inevitable challenge to the success of cancer treatment. Recently, in ovarian cancer, a highly chemoresistant tumor, we demonstrated an important role of shear stress in stem-like phenotype and chemoresistance using a three-dimensional microfluidic device, which most...

Descripción completa

Detalles Bibliográficos
Autores principales: Hassan, Ayon A., Artemenko, Margarita, Tang, Maggie K. S., Shi, Zeyu, Chen, Lin-Yu, Lai, Hung-Cheng, Yang, Zhenyu, Shum, Ho-Cheung, Wong, Alice S. T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9177676/
https://www.ncbi.nlm.nih.gov/pubmed/35676254
http://dx.doi.org/10.1038/s41419-022-04976-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9177676/
https://www.ncbi.nlm.nih.gov/pubmed/35676254
http://dx.doi.org/10.1038/s41419-022-04976-6

Ejemplares similares