Cargando…

Brain aging is faithfully modelled in organotypic brain slices and accelerated by prions

Mammalian models are essential for brain aging research. However, the long lifespan and poor amenability to genetic and pharmacological perturbations have hindered the use of mammals for dissecting aging-regulatory molecular networks and discovering new anti-aging interventions. To circumvent these...

Descripción completa

Detalles Bibliográficos
Autores principales:	Liu, Yingjun, Senatore, Assunta, Sorce, Silvia, Nuvolone, Mario, Guo, Jingjing, Gümüş, Zeynep H., Aguzzi, Adriano
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9177860/ https://www.ncbi.nlm.nih.gov/pubmed/35676449 http://dx.doi.org/10.1038/s42003-022-03496-5

Ejemplares similares

Author Correction: Brain aging is faithfully modelled in organotypic brain slices and accelerated by prions
por: Liu, Yingjun, et al.
Publicado: (2022)

Prion Pathogenesis Is Faithfully Reproduced in Cerebellar Organotypic Slice Cultures
por: Falsig, Jeppe, et al.
Publicado: (2012)

Glial activation in prion diseases is selectively triggered by neuronal PrP(Sc)
por: Lakkaraju, Asvin K. K., et al.
Publicado: (2022)

Lymphocyte activation gene 3 (Lag3) expression is increased in prion infections but does not modify disease progression
por: Liu, Yingjun, et al.
Publicado: (2018)

Prion Pathogenesis in the Absence of NLRP3/ASC Inflammasomes
por: Nuvolone, Mario, et al.
Publicado: (2015)

Neurotoxic Antibodies against the Prion Protein Do Not Trigger Prion Replication
por: Frontzek, Karl, et al.
Publicado: (2016)

Prion pathogenesis is unaltered in the absence of SIRPα-mediated "don't-eat-me" signaling
por: Nuvolone, Mario, et al.
Publicado: (2017)

The Role of the NADPH Oxidase NOX2 in Prion Pathogenesis
por: Sorce, Silvia, et al.
Publicado: (2014)

The biological function of the cellular prion protein: an update
por: Wulf, Marie-Angela, et al.
Publicado: (2017)

Strictly co-isogenic C57BL/6J-Prnp(−/−) mice: A rigorous resource for prion science
por: Nuvolone, Mario, et al.
Publicado: (2016)

ORGANOTYPIC BRAIN SLICE CULTURES: A REVIEW
por: HUMPEL, C.
Publicado: (2015)

Protective anti‐prion antibodies in human immunoglobulin repertoires
por: Senatore, Assunta, et al.
Publicado: (2020)

Inhibition of group-I metabotropic glutamate receptors protects against prion toxicity
por: Goniotaki, Despoina, et al.
Publicado: (2017)

Organotypic brain slice cultures to model neurodegenerative proteinopathies
por: Croft, C. L., et al.
Publicado: (2019)

Microcontact Printing of Cholinergic Neurons in Organotypic Brain Slices
por: Steiner, Katharina, et al.
Publicado: (2021)

Soluble dimeric prion protein ligand activates Adgrg6 receptor but does not rescue early signs of demyelination in PrP-deficient mice
por: Henzi, Anna, et al.
Publicado: (2020)

Genome-wide transcriptomics identifies an early preclinical signature of prion infection
por: Sorce, Silvia, et al.
Publicado: (2020)

POSCAbilities: The Application of the Prion Organotypic Slice Culture Assay to Neurodegenerative Disease Research
por: Pineau, Hailey, et al.
Publicado: (2020)

A role for astroglia in prion diseases
por: Aguzzi, Adriano, et al.
Publicado: (2017)

Preparation of organotypic brain slice cultures for the study of Alzheimer’s disease
por: Croft, Cara L., et al.
Publicado: (2018)

Organotypic brain slice cultures as a model to study angiogenesis of brain vessels
por: Hutter-Schmid, Bianca, et al.
Publicado: (2015)

Correlation of in vitro infiltration with glioma histological type in organotypic brain slices
por: Palfi, S, et al.
Publicado: (2004)

Spreading of Aggregated α-Synuclein in Sagittal Organotypic Mouse Brain Slices
por: Uçar, Buket, et al.
Publicado: (2022)

Alternative Brain Slice-on-a-Chip for Organotypic Culture and Effective Fluorescence Injection Testing
por: Herreros, Pedro, et al.
Publicado: (2022)

SARM1 deficiency up-regulates XAF1, promotes neuronal apoptosis, and accelerates prion disease
por: Zhu, Caihong, et al.
Publicado: (2019)

Prion pathogenesis is unaltered in a mouse strain with a permeable blood-brain barrier
por: Keller, Annika, et al.
Publicado: (2018)

Cystatin F is a biomarker of prion pathogenesis in mice
por: Nuvolone, Mario, et al.
Publicado: (2017)

A neuroprotective role for microglia in prion diseases
por: Zhu, Caihong, et al.
Publicado: (2016)

Coculture System with an Organotypic Brain Slice and 3D Spheroid of Carcinoma Cells
por: Chuang, Han-Ning, et al.
Publicado: (2013)

An advanced glioma cell invasion assay based on organotypic brain slice cultures
por: Eisemann, Tanja, et al.
Publicado: (2018)

Expansion microscopy of mouse brain organotypic slice cultures to study protein distribution
por: Bissen, Diane, et al.
Publicado: (2022)

An In Vitro Brain Tumour Model in Organotypic Slice Cultures Displaying Epileptiform Activity
por: Chong, Harvey K., et al.
Publicado: (2023)

Prion protein and Aβ-related synaptic toxicity impairment
por: Calella, Anna Maria, et al.
Publicado: (2010)

SIRPα polymorphisms, but not the prion protein, control phagocytosis of apoptotic cells
por: Nuvolone, Mario, et al.
Publicado: (2013)

Organotypic brain slices: a model to study the neurovascular unit micro-environment in epilepsies
por: Morin-Brureau, Mélanie, et al.
Publicado: (2013)

Regioselective Biolistic Targeting in Organotypic Brain Slices Using a Modified Gene Gun
por: Arsenault, Jason, et al.
Publicado: (2014)

Desflurane impairs outcome of organotypic hippocampal slices in an in vitro model of traumatic brain injury
por: Krings, Matthias, et al.
Publicado: (2016)

Time lapse recording of cortical interneuron migration in mouse organotypic brain slices and explants
por: Lepiemme, Fanny, et al.
Publicado: (2021)

Spreading of P301S Aggregated Tau Investigated in Organotypic Mouse Brain Slice Cultures
por: Korde, Dhwani S., et al.
Publicado: (2022)

Deposition pattern and subcellular distribution of disease-associated prion protein in cerebellar organotypic slice cultures infected with scrapie
por: Wolf, Hanna, et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_5aalaa8cjbp5vp8dg2ook5bkh0