Antispacer peptide nucleic acids for sequence-specific CRISPR-Cas9 modulation

Despite the rapid and broad implementation of CRISPR-Cas9-based technologies, convenient tools to modulate dose, timing, and precision remain limited. Building on methods using synthetic peptide nucleic acids (PNAs) to bind RNA with unusually high affinity, we describe guide RNA (gRNA) spacer-target...

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Detalles Bibliográficos
Autores principales: Economos, Nicholas G, Quijano, Elias, Carufe, Kelly E W, Perera, J Dinithi R, Glazer, Peter M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Methods Online
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9177974/
https://www.ncbi.nlm.nih.gov/pubmed/35235944
http://dx.doi.org/10.1093/nar/gkac095

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9177974/
https://www.ncbi.nlm.nih.gov/pubmed/35235944
http://dx.doi.org/10.1093/nar/gkac095

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