GNAT toxins evolve toward narrow tRNA target specificities

Type II toxin–antitoxin (TA) systems are two-gene modules widely distributed among prokaryotes. GNAT toxins associated with the DUF1778 antitoxins represent a large family of type II TAs. GNAT toxins inhibit cell growth by disrupting translation via acetylation of aminoacyl-tRNAs. In this work, we e...

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Detalles Bibliográficos
Autores principales: Bikmetov, Dmitry, Hall, Alexander M J, Livenskyi, Alexei, Gollan, Bridget, Ovchinnikov, Stepan, Gilep, Konstantin, Kim, Jenny Y, Larrouy-Maumus, Gerald, Zgoda, Viktor, Borukhov, Sergei, Severinov, Konstantin, Helaine, Sophie, Dubiley, Svetlana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
RNA and RNA-protein complexes
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9177977/
https://www.ncbi.nlm.nih.gov/pubmed/35609997
http://dx.doi.org/10.1093/nar/gkac356

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9177977/
https://www.ncbi.nlm.nih.gov/pubmed/35609997
http://dx.doi.org/10.1093/nar/gkac356

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