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GNAT toxins evolve toward narrow tRNA target specificities

Type II toxin–antitoxin (TA) systems are two-gene modules widely distributed among prokaryotes. GNAT toxins associated with the DUF1778 antitoxins represent a large family of type II TAs. GNAT toxins inhibit cell growth by disrupting translation via acetylation of aminoacyl-tRNAs. In this work, we e...

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Detalles Bibliográficos
Autores principales:	Bikmetov, Dmitry, Hall, Alexander M J, Livenskyi, Alexei, Gollan, Bridget, Ovchinnikov, Stepan, Gilep, Konstantin, Kim, Jenny Y, Larrouy-Maumus, Gerald, Zgoda, Viktor, Borukhov, Sergei, Severinov, Konstantin, Helaine, Sophie, Dubiley, Svetlana
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2022
Materias:	RNA and RNA-protein complexes
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9177977/ https://www.ncbi.nlm.nih.gov/pubmed/35609997 http://dx.doi.org/10.1093/nar/gkac356

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