Histone H3K27 demethylase UTX compromises articular chondrocyte anabolism and aggravates osteoarthritic degeneration

Epigenome alteration in chondrocytes correlates with osteoarthritis (OA) development. H3K27me3 demethylase UTX regulates tissue homeostasis and deterioration, while its role was not yet studied in articulating joint tissue in situ. We now uncovered that increased UTX and H3K27me3 expression in artic...

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Detalles Bibliográficos
Autores principales: Lian, Wei-Shiung, Wu, Re-Wen, Ko, Jih-Yang, Chen, Yu-Shan, Wang, Shao-Yu, Yu, Chun-Ping, Jahr, Holger, Wang, Feng-Sheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9178009/
https://www.ncbi.nlm.nih.gov/pubmed/35676242
http://dx.doi.org/10.1038/s41419-022-04985-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9178009/
https://www.ncbi.nlm.nih.gov/pubmed/35676242
http://dx.doi.org/10.1038/s41419-022-04985-5

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