DNA-PK(cs)-dependent phosphorylation of RECQL4 promotes NHEJ by stabilizing the NHEJ machinery at DNA double-strand breaks

Non-homologous end joining (NHEJ) is the major pathway that mediates the repair of DNA double-strand breaks (DSBs) generated by ionizing radiation (IR). Previously, the DNA helicase RECQL4 was implicated in promoting NHEJ, but its role in the pathway remains unresolved. In this study, we report that...

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Detalles Bibliográficos
Autores principales: Lu, Huiming, Guan, Junhong, Wang, Shih-Ya, Li, Guo-Min, Bohr, Vilhelm A, Davis, Anthony J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Genome Integrity, Repair and Replication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9178012/
https://www.ncbi.nlm.nih.gov/pubmed/35580045
http://dx.doi.org/10.1093/nar/gkac375

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9178012/
https://www.ncbi.nlm.nih.gov/pubmed/35580045
http://dx.doi.org/10.1093/nar/gkac375

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