The caspase-6–p62 axis modulates p62 droplets based autophagy in a dominant-negative manner

SQSTM1/p62, as a major autophagy receptor, forms droplets that are critical for cargo recognition, nucleation, and clearance. p62 droplets also function as liquid assembly platforms to allow the formation of autophagosomes at their surfaces. It is unknown how p62-droplet formation is regulated under...

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Detalles Bibliográficos
Autores principales: Valionyte, Evelina, Yang, Yi, Griffiths, Sophie A., Bone, Amelia T., Barrow, Elizabeth R., Sharma, Vikram, Lu, Boxun, Luo, Shouqing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9178044/
https://www.ncbi.nlm.nih.gov/pubmed/34862482
http://dx.doi.org/10.1038/s41418-021-00912-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9178044/
https://www.ncbi.nlm.nih.gov/pubmed/34862482
http://dx.doi.org/10.1038/s41418-021-00912-x

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