PHACT: Phylogeny-Aware Computing of Tolerance for Missense Mutations

Evolutionary conservation is a fundamental resource for predicting the substitutability of amino acids and the loss of function in proteins. The use of multiple sequence alignment alone—without considering the evolutionary relationships among sequences—results in the redundant counting of evolutiona...

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Detalles Bibliográficos
Autores principales: Kuru, Nurdan, Dereli, Onur, Akkoyun, Emrah, Bircan, Aylin, Tastan, Oznur, Adebali, Ogun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Methods
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9178230/
https://www.ncbi.nlm.nih.gov/pubmed/35639618
http://dx.doi.org/10.1093/molbev/msac114

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9178230/
https://www.ncbi.nlm.nih.gov/pubmed/35639618
http://dx.doi.org/10.1093/molbev/msac114

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