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PHACT: Phylogeny-Aware Computing of Tolerance for Missense Mutations
Evolutionary conservation is a fundamental resource for predicting the substitutability of amino acids and the loss of function in proteins. The use of multiple sequence alignment alone—without considering the evolutionary relationships among sequences—results in the redundant counting of evolutiona...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Oxford University Press
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9178230/ https://www.ncbi.nlm.nih.gov/pubmed/35639618 http://dx.doi.org/10.1093/molbev/msac114 |