Inhibition of Cyclin-Dependent Kinase 9 Downregulates Cytokine Production Without Detrimentally Affecting Human Monocyte-Derived Macrophage Viability

Cyclin-dependent kinase (CDK) inhibitor drugs (CDKi), such as R-roscovitine and AT7519, induce neutrophil apoptosis in vitro and enhance the resolution of inflammation in a number of in vivo models. This class of compounds are potential novel therapeutic agents that could promote the resolution of a...

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Detalles Bibliográficos
Autores principales: McHugh, Brian J., Stephen, Jillian, Robb, Calum T., Fox, Sarah, Kipari, Tiina, Cartwright, Jennifer A., Haslett, Christopher, Duffin, Rodger, Lucas, Christopher D., Rossi, Adriano G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Cell and Developmental Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9178253/
https://www.ncbi.nlm.nih.gov/pubmed/35693926
http://dx.doi.org/10.3389/fcell.2022.905315

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9178253/
https://www.ncbi.nlm.nih.gov/pubmed/35693926
http://dx.doi.org/10.3389/fcell.2022.905315

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