Chemoselective O-Alkylation of 4-(Trifluoromethyl)pyrimidin-2(1H)-ones Using 4-(Iodomethyl)pyrimidines

[Image: see text] This study reports two strategies for preparing O-alkyl derivatives of 6-substituted-4-(trifluoromethyl)pyrimidin-(1H)-ones: a linear protocol of alkylation, using a CCC-building block followed by [3 + 3]-type cyclocondensation with 2-methylisothiourea sulfate and a convergent prot...

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Detalles Bibliográficos
Autores principales: Mittersteiner, Mateus, Pereira, Genilson S., Wessjohann, Ludger A., Bonacorso, Helio G., Martins, Marcos A. P., Zanatta, Nilo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9178747/
https://www.ncbi.nlm.nih.gov/pubmed/35694463
http://dx.doi.org/10.1021/acsomega.2c01925

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9178747/
https://www.ncbi.nlm.nih.gov/pubmed/35694463
http://dx.doi.org/10.1021/acsomega.2c01925

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