Tuning Enzyme Thermostability via Computationally Guided Covalent Stapling and Structural Basis of Enhanced Stabilization

[Image: see text] Enhancing the thermostability of enzymes without impacting their catalytic function represents an important yet challenging goal in protein engineering and biocatalysis. We recently introduced a novel method for enzyme thermostabilization that relies on the computationally guided i...

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Detalles Bibliográficos
Autores principales: Iannuzzelli, Jacob A., Bacik, John-Paul, Moore, Eric J., Shen, Zhuofan, Irving, Ellen M., Vargas, David A., Khare, Sagar D., Ando, Nozomi, Fasan, Rudi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9178789/
https://www.ncbi.nlm.nih.gov/pubmed/35612958
http://dx.doi.org/10.1021/acs.biochem.2c00033

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9178789/
https://www.ncbi.nlm.nih.gov/pubmed/35612958
http://dx.doi.org/10.1021/acs.biochem.2c00033

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