Virtual Quasi-2D Intermediates as Building Blocks for Plausible Structural Models of Amyloid Fibrils from Proteins with Complex Topologies: A Case Study of Insulin

[Image: see text] Conformational transitions of globular proteins into amyloid fibrils are complex multistage processes exceedingly challenging to simulate using molecular dynamics (MD). Slow monomer diffusion rates and rugged free energy landscapes disfavor swift self-assembly of orderly amyloid ar...

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Detalles Bibliográficos
Autores principales: Puławski, Wojciech, Dzwolak, Wojciech
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9178918/
https://www.ncbi.nlm.nih.gov/pubmed/35617668
http://dx.doi.org/10.1021/acs.langmuir.2c00699

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9178918/
https://www.ncbi.nlm.nih.gov/pubmed/35617668
http://dx.doi.org/10.1021/acs.langmuir.2c00699

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