Significance of Specific Oxidoreductases in the Design of Hypoxia-Activated Prodrugs and Fluorescent Turn off–on Probes for Hypoxia Imaging

SIMPLE SUMMARY: Hypoxia-activated prodrugs (HAPs), selectively reduced by specific oxidoreductases under hypoxic conditions, form cytotoxic agents damaging the local cancer cells. On the basis of the reported clinical data concerning several HAPs, one can draw conclusions regarding their preclinical...

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Detalles Bibliográficos
Autores principales: Janczy-Cempa, Ewelina, Mazuryk, Olga, Kania, Agnieszka, Brindell, Małgorzata
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9179281/
https://www.ncbi.nlm.nih.gov/pubmed/35681666
http://dx.doi.org/10.3390/cancers14112686

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9179281/
https://www.ncbi.nlm.nih.gov/pubmed/35681666
http://dx.doi.org/10.3390/cancers14112686

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