Therapeutic Validation of GEF-H1 Using a De Novo Designed Inhibitor in Models of Retinal Disease

Inflammation and fibrosis are important components of diseases that contribute to the malfunction of epithelia and endothelia. The Rho guanine nucleotide exchange factor (GEF) GEF-H1/ARHGEF-2 is induced in disease and stimulates inflammatory and fibrotic processes, cell migration, and metastasis. He...

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Detalles Bibliográficos
Autores principales: Mills, Clare, Hemkemeyer, Sandra A., Alimajstorovic, Zerin, Bowers, Chantelle, Eskandarpour, Malihe, Greenwood, John, Calder, Virginia, Chan, A. W. Edith, Gane, Paul J., Selwood, David L., Matter, Karl, Balda, Maria S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9179336/
https://www.ncbi.nlm.nih.gov/pubmed/35681428
http://dx.doi.org/10.3390/cells11111733

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9179336/
https://www.ncbi.nlm.nih.gov/pubmed/35681428
http://dx.doi.org/10.3390/cells11111733

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