Design of New Potent and Selective Thiophene-Based K(V)1.3 Inhibitors and Their Potential for Anticancer Activity

SIMPLE SUMMARY: In this article, we describe the discovery of a new class of potent and selective thiophene-based inhibitors of the voltage-gated potassium channel K(V)1.3 and their potential to induce apoptosis and inhibit proliferation. The K(V)1.3 channel has only recently emerged as a molecular...

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Detalles Bibliográficos
Autores principales: Gubič, Špela, Hendrickx, Louise Antonia, Shi, Xiaoyi, Toplak, Žan, Možina, Štefan, Theemsche, Kenny M. Van, Pinheiro-Junior, Ernesto Lopes, Peigneur, Steve, Labro, Alain J., Pardo, Luis A., Tytgat, Jan, Tomašič, Tihomir, Mašič, Lucija Peterlin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9179341/
https://www.ncbi.nlm.nih.gov/pubmed/35681571
http://dx.doi.org/10.3390/cancers14112595

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9179341/
https://www.ncbi.nlm.nih.gov/pubmed/35681571
http://dx.doi.org/10.3390/cancers14112595

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