Inhibitors of the Actin-Bundling Protein Fascin-1 Developed for Tumor Therapy Attenuate the T-Cell Stimulatory Properties of Dendritic Cells

SIMPLE SUMMARY: Expression of the actin-bundling protein Fascin-1 (Fscn1) is largely restricted to neuronal cells and to activated dendritic cells (DCs). DCs are important inducers of (antitumor) immune responses. In tumor cells, de novo expression of Fscn-1 correlates with their invasive and metast...

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Detalles Bibliográficos
Autores principales: Zeyn, Yanira, Harms, Gregory, Tubbe, Ingrid, Montermann, Evelyn, Röhrig, Nadine, Hartmann, Maike, Grabbe, Stephan, Bros, Matthias
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9179534/
https://www.ncbi.nlm.nih.gov/pubmed/35681718
http://dx.doi.org/10.3390/cancers14112738

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9179534/
https://www.ncbi.nlm.nih.gov/pubmed/35681718
http://dx.doi.org/10.3390/cancers14112738

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