Pharmacologic Induction of BRCAness in BRCA-Proficient Cancers: Expanding PARP Inhibitor Use

SIMPLE SUMMARY: BRCA1 and−2 are critical components of the homologous recombination pathway of DNA repair required to effectively repair DNA double strand breaks, leading to an increased cancer risk in patients with inherited BRCA mutations. An additional subset of cancers exhibit ‘BRCAness’, harbor...

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Detalles Bibliográficos
Autores principales: Abbotts, Rachel, Dellomo, Anna J., Rassool, Feyruz V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9179544/
https://www.ncbi.nlm.nih.gov/pubmed/35681619
http://dx.doi.org/10.3390/cancers14112640

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9179544/
https://www.ncbi.nlm.nih.gov/pubmed/35681619
http://dx.doi.org/10.3390/cancers14112640

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