Mutation of Methionine to Asparagine but Not Leucine in Parathyroid Hormone Mimics the Loss of Biological Function upon Oxidation

[Image: see text] Human parathyroid hormone (PTH) is an 84-amino acid peptide that contains two methionine (Met) residues located at positions 8 and 18. It has long been recognized that Met residues in PTH are subject to oxidation to become Met sulfoxide, resulting in a decreased biological function...

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Detalles Bibliográficos
Autores principales: Gaur, Amit, Lipponen, Jessica, Yang, Yanmei, Armen, Roger S., Wang, Bin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9179810/
https://www.ncbi.nlm.nih.gov/pubmed/35533300
http://dx.doi.org/10.1021/acs.biochem.2c00200

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9179810/
https://www.ncbi.nlm.nih.gov/pubmed/35533300
http://dx.doi.org/10.1021/acs.biochem.2c00200

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