Inhibition of a Mitochondrial Potassium Channel in Combination with Gemcitabine and Abraxane Drastically Reduces Pancreatic Ductal Adenocarcinoma in an Immunocompetent Orthotopic Murine Model

SIMPLE SUMMARY: Treatment of pancreas ductal adenocarcinoma (PDAC) remains challenging due to the late stage of presentation, limited efficacy of cytotoxic chemotherapies, and aggressive tumor biology. Novel therapeutic targets are desperately needed. The voltage-gated potassium channel, Kv1.3, is o...

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Detalles Bibliográficos
Autores principales: Li, Weiwei, Wilson, Gregory C., Bachmann, Magdalena, Wang, Jiang, Mattarei, Andrea, Paradisi, Cristina, Edwards, Michael J., Szabo, Ildiko, Gulbins, Erich, Ahmad, Syed A., Patel, Sameer H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9179813/
https://www.ncbi.nlm.nih.gov/pubmed/35681598
http://dx.doi.org/10.3390/cancers14112618

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9179813/
https://www.ncbi.nlm.nih.gov/pubmed/35681598
http://dx.doi.org/10.3390/cancers14112618

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