Gallic Acid: A Natural Phenolic Compound Exerting Antitumoral Activities in Colorectal Cancer via Interaction with G-Quadruplexes

SIMPLE SUMMARY: Gallic acid, a natural phenolic compound in diet, interacts with DNA G-quadruplexes both in vitro and in vivo. In particular, gallic acid targets G-quadruplexes in ribosomal DNA and CMYC oncogene, affecting gene expression. This action leads to antitumoral effects in colorectal cance...

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Detalles Bibliográficos
Autores principales: Sanchez-Martin, Victoria, Plaza-Calonge, María del Carmen, Soriano-Lerma, Ana, Ortiz-Gonzalez, Matilde, Linde-Rodriguez, Angel, Perez-Carrasco, Virginia, Ramirez-Macias, Inmaculada, Cuadros, Marta, Gutierrez-Fernandez, Jose, Murciano-Calles, Javier, Rodríguez-Manzaneque, Juan Carlos, Soriano, Miguel, Garcia-Salcedo, Jose Antonio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9179882/
https://www.ncbi.nlm.nih.gov/pubmed/35681628
http://dx.doi.org/10.3390/cancers14112648

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9179882/
https://www.ncbi.nlm.nih.gov/pubmed/35681628
http://dx.doi.org/10.3390/cancers14112648

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