Novel Cyclopentaquinoline and Acridine Analogs as Multifunctional, Potent Drug Candidates in Alzheimer’s Disease

A series of new cyclopentaquinoline derivatives with 9-acridinecarboxylic acid and a different alkyl chain length were synthesized, and their ability to inhibit cholinesterases was evaluated. All designed compounds, except derivative 3f, exhibited a selectivity for butyrylcholinesterase (BuChE) with...

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Detalles Bibliográficos
Autores principales: Maciejewska, Karolina, Czarnecka, Kamila, Kręcisz, Paweł, Niedziałek, Dorota, Wieczorek, Grzegorz, Skibiński, Robert, Szymański, Paweł
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9179981/
https://www.ncbi.nlm.nih.gov/pubmed/35682556
http://dx.doi.org/10.3390/ijms23115876

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9179981/
https://www.ncbi.nlm.nih.gov/pubmed/35682556
http://dx.doi.org/10.3390/ijms23115876

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