Correction of Beta-Thalassemia IVS-II-654 Mutation in a Mouse Model Using Prime Editing

Prime editing was used to insert and correct various pathogenic mutations except for beta-thalassemia variants, which disrupt functional beta-globin and prevent hemoglobin assembly in erythrocytes. This study investigated the effect of gene correction using prime editor version 3 (PE3) in a mouse mo...

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Detalles Bibliográficos
Autores principales: Zhang, Haokun, Sun, Ruilin, Fei, Jian, Chen, Hongyan, Lu, Daru
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9180235/
https://www.ncbi.nlm.nih.gov/pubmed/35682629
http://dx.doi.org/10.3390/ijms23115948

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9180235/
https://www.ncbi.nlm.nih.gov/pubmed/35682629
http://dx.doi.org/10.3390/ijms23115948

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