A Unique Spectrum of Spontaneous Tumors in Dino Knockout Mice Identifies Tissue-Specific Requirements for Tumor Suppression

Here, we report that Dino, a lncRNA required for p53 signaling, suppresses spontaneous tumorigenesis in mice. Dino(−/−) mice develop significantly more malignant tumors than Dino(+/+) littermate controls, consisting predominantly of sarcomas, B cell lymphomas and additional rare tumors. While the pr...

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Detalles Bibliográficos
Autores principales: Marney, Christina B., Anderson, Erik S., Baum, Rachel, Schmitt, Adam M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9180304/
https://www.ncbi.nlm.nih.gov/pubmed/35681513
http://dx.doi.org/10.3390/cells11111818

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9180304/
https://www.ncbi.nlm.nih.gov/pubmed/35681513
http://dx.doi.org/10.3390/cells11111818

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