Arginine-Containing Tripeptides as Analgesic Substances: The Possible Mechanism of Ligand-Receptor Binding to the Slow Sodium Channel

Two short arginine-containing tripeptides, H-Arg-Arg-Arg-OH (TP1) and Ac-Arg-Arg-Arg-NH(2) (TP2), have been shown by the patch-clamp method to modulate the Na(V)1.8 channels of DRG primary sensory neurons, which are responsible for the generation of nociceptive signals. Conformational analysis of th...

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Detalles Bibliográficos
Autores principales: Rogachevskii, Ilya V., Plakhova, Vera B., Penniyaynen, Valentina A., Kalinina, Arina D., Podzorova, Svetlana A., Samosvat, Dmitriy M., Zegrya, Georgy G., Krylov, Boris V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9180558/
https://www.ncbi.nlm.nih.gov/pubmed/35682672
http://dx.doi.org/10.3390/ijms23115993

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9180558/
https://www.ncbi.nlm.nih.gov/pubmed/35682672
http://dx.doi.org/10.3390/ijms23115993

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