Arginine-Containing Tripeptides as Analgesic Substances: The Possible Mechanism of Ligand-Receptor Binding to the Slow Sodium Channel

Two short arginine-containing tripeptides, H-Arg-Arg-Arg-OH (TP1) and Ac-Arg-Arg-Arg-NH(2) (TP2), have been shown by the patch-clamp method to modulate the Na(V)1.8 channels of DRG primary sensory neurons, which are responsible for the generation of nociceptive signals. Conformational analysis of th...

Descripción completa

Detalles Bibliográficos
Autores principales: Rogachevskii, Ilya V., Plakhova, Vera B., Penniyaynen, Valentina A., Kalinina, Arina D., Podzorova, Svetlana A., Samosvat, Dmitriy M., Zegrya, Georgy G., Krylov, Boris V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9180558/
https://www.ncbi.nlm.nih.gov/pubmed/35682672
http://dx.doi.org/10.3390/ijms23115993

Ejemplares similares

Ejemplares similares