LDHB Overexpression Can Partially Overcome T Cell Inhibition by Lactic Acid

Accelerated glycolysis leads to secretion and accumulation of lactate and protons in the tumor environment and determines the efficacy of adoptive T cell and checkpoint inhibition therapy. Here, we analyzed effects of lactic acid on different human CD4 T cell subsets and aimed to increase CD4 T cell...

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Detalles Bibliográficos
Autores principales: Decking, Sonja-Maria, Bruss, Christina, Babl, Nathalie, Bittner, Sebastian, Klobuch, Sebastian, Thomas, Simone, Feuerer, Markus, Hoffmann, Petra, Dettmer, Katja, Oefner, Peter J., Renner, Kathrin, Kreutz, Marina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9180663/
https://www.ncbi.nlm.nih.gov/pubmed/35682650
http://dx.doi.org/10.3390/ijms23115970

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9180663/
https://www.ncbi.nlm.nih.gov/pubmed/35682650
http://dx.doi.org/10.3390/ijms23115970

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