Molecular Mechanism of Pathogenesis and Treatment Strategies for AL Amyloidosis

In amyloid light-chain (AL) amyloidosis, small B-cell clones (mostly plasma cell clones) present in the bone marrow proliferate and secrete unstable monoclonal free light chains (FLCs), which form amyloid fibrils that deposit in the interstitial tissue, resulting in organ injury and dysfunction. AL...

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Detalles Bibliográficos
Autores principales: Ikura, Hidehiko, Endo, Jin, Kitakata, Hiroki, Moriyama, Hidenori, Sano, Motoaki, Fukuda, Keiichi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9181426/
https://www.ncbi.nlm.nih.gov/pubmed/35683015
http://dx.doi.org/10.3390/ijms23116336

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9181426/
https://www.ncbi.nlm.nih.gov/pubmed/35683015
http://dx.doi.org/10.3390/ijms23116336

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