Novel Epoxides of Soloxolone Methyl: An Effect of the Formation of Oxirane Ring and Stereoisomerism on Cytotoxic Profile, Anti-Metastatic and Anti-Inflammatory Activities In Vitro and In Vivo

It is known that epoxide-bearing compounds display pronounced pharmacological activities, and the epoxidation of natural metabolites can be a promising strategy to improve their bioactivity. Here, we report the design, synthesis and evaluation of biological properties of αO-SM and βO-SM, novel epoxi...

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Detalles Bibliográficos
Autores principales: Salomatina, Oksana V., Sen’kova, Aleksandra V., Moralev, Arseny D., Savin, Innokenty A., Komarova, Nina I., Salakhutdinov, Nariman F., Zenkova, Marina A., Markov, Andrey V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9181525/
https://www.ncbi.nlm.nih.gov/pubmed/35682893
http://dx.doi.org/10.3390/ijms23116214

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9181525/
https://www.ncbi.nlm.nih.gov/pubmed/35682893
http://dx.doi.org/10.3390/ijms23116214

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