Carboplatin-Induced Thrombocytopenia through JAK2 Downregulation, S-Phase Cell Cycle Arrest and Apoptosis in Megakaryocytes

Chemotherapy-induced thrombocytopenia (CIT) is a common complication when treating malignancies with cytotoxic agents wherein carboplatin is one of the most typical agents causing CIT. Janus kinase 2 (JAK2) is one of the critical enzymes to megakaryocyte proliferation and differentiation. However, t...

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Detalles Bibliográficos
Autores principales: Wu, Yi-Hong, Chen, Hsing-Yu, Hong, Wei-Chin, Wei, Chen-Ying, Pang, Jong-Hwei Su
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9181531/
https://www.ncbi.nlm.nih.gov/pubmed/35682967
http://dx.doi.org/10.3390/ijms23116290

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9181531/
https://www.ncbi.nlm.nih.gov/pubmed/35682967
http://dx.doi.org/10.3390/ijms23116290

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