Deletion of the Autism-Associated Protein SHANK3 Abolishes Structural Synaptic Plasticity after Brain Trauma

Autism spectrum disorders (ASDs) are characterized by repetitive behaviors and impairments of sociability and communication. About 1% of ASD cases are caused by mutations of SHANK3, a major scaffolding protein of the postsynaptic density. We studied the role of SHANK3 in plastic changes of excitator...

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Detalles Bibliográficos
Autores principales: Urrutia-Ruiz, Carolina, Rombach, Daniel, Cursano, Silvia, Gerlach-Arbeiter, Susanne, Schoen, Michael, Bockmann, Juergen, Demestre, Maria, Boeckers, Tobias M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9181590/
https://www.ncbi.nlm.nih.gov/pubmed/35682760
http://dx.doi.org/10.3390/ijms23116081

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9181590/
https://www.ncbi.nlm.nih.gov/pubmed/35682760
http://dx.doi.org/10.3390/ijms23116081

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