Anti-Growth, Anti-Angiogenic, and Pro-Apoptotic Effects by CX-4945, an Inhibitor of Casein Kinase 2, on HuCCT-1 Human Cholangiocarcinoma Cells via Control of Caspase-9/3, DR-4, STAT-3/STAT-5, Mcl-1, eIF-2α, and HIF-1α

Overexpression of casein kinase 2 (CK2) has an oncogenic and pro-survival role in many cancers. CX-4945 (Silmitasertib) is a CK2 inhibitor with anti-cancerous and anti-angiogenic effects. Up to date, the anti-cancer effect and mechanism of CX-4945 on human cholangiocarcinoma (CCA) remain unclear. Th...

Descripción completa

Detalles Bibliográficos
Autores principales: Wang, Saini, Yadav, Anil Kumar, Han, Jin-Yi, Ahn, Keun Soo, Jang, Byeong-Churl
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9181600/
https://www.ncbi.nlm.nih.gov/pubmed/35683032
http://dx.doi.org/10.3390/ijms23116353

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9181600/
https://www.ncbi.nlm.nih.gov/pubmed/35683032
http://dx.doi.org/10.3390/ijms23116353

Ejemplares similares