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Cryo-EM structures show the mechanistic basis of pan-peptidase inhibition by human α(2)-macroglobulin
Human α(2)-macroglobulin (hα(2)M) is a multidomain protein with a plethora of essential functions, including transport of signaling molecules and endopeptidase inhibition in innate immunity. Here, we dissected the molecular mechanism of the inhibitory function of the ∼720-kDa hα(2)M tetramer through...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
National Academy of Sciences
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9181621/ https://www.ncbi.nlm.nih.gov/pubmed/35500114 http://dx.doi.org/10.1073/pnas.2200102119 |