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Cryo-EM structures show the mechanistic basis of pan-peptidase inhibition by human α(2)-macroglobulin

Human α(2)-macroglobulin (hα(2)M) is a multidomain protein with a plethora of essential functions, including transport of signaling molecules and endopeptidase inhibition in innate immunity. Here, we dissected the molecular mechanism of the inhibitory function of the ∼720-kDa hα(2)M tetramer through...

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Detalles Bibliográficos
Autores principales:	Luque, Daniel, Goulas, Theodoros, Mata, Carlos P., Mendes, Soraia R., Gomis-Rüth, F. Xavier, Castón, José R.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	National Academy of Sciences 2022
Materias:	Biological Sciences
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9181621/ https://www.ncbi.nlm.nih.gov/pubmed/35500114 http://dx.doi.org/10.1073/pnas.2200102119

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