Early adaptive chromatin remodeling events precede pathologic phenotypes and are reinforced in the failing heart

The temporal nature of chromatin structural changes underpinning pathologic transcription are poorly understood. We measured chromatin accessibility and DNA methylation to study the contribution of chromatin remodeling at different stages of cardiac hypertrophy and failure. ATAC-seq and reduced repr...

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Detalles Bibliográficos
Autores principales: Chapski, Douglas J., Cabaj, Maximilian, Morselli, Marco, Mason, Rosibel J., Soehalim, Elizabeth, Ren, Shuxun, Pellegrini, Matteo, Wang, Yibin, Vondriska, Thomas M., Rosa-Garrido, Manuel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9181638/
https://www.ncbi.nlm.nih.gov/pubmed/34273410
http://dx.doi.org/10.1016/j.yjmcc.2021.07.002

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9181638/
https://www.ncbi.nlm.nih.gov/pubmed/34273410
http://dx.doi.org/10.1016/j.yjmcc.2021.07.002

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