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Early adaptive chromatin remodeling events precede pathologic phenotypes and are reinforced in the failing heart
The temporal nature of chromatin structural changes underpinning pathologic transcription are poorly understood. We measured chromatin accessibility and DNA methylation to study the contribution of chromatin remodeling at different stages of cardiac hypertrophy and failure. ATAC-seq and reduced repr...
| Autores principales: | , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9181638/ https://www.ncbi.nlm.nih.gov/pubmed/34273410 http://dx.doi.org/10.1016/j.yjmcc.2021.07.002 |