Synthesis and Anti-Neuroinflammatory Activity of 1,7-diphenyl-1,4-heptadien-3-ones in LPS-Stimulated BV2 Microglia Via Inhibiting NF-κB/MAPK Signaling Pathways

A series of 1,7-diphenyl-1,4-heptadien-3-ones with various substituents (HO-, CH(3)O-, CH(3)-, Cl-) on the phenyl rings were synthesized and evaluated for anti-neuroinflammatory effects in LPS-stimulated BV2 microglia. The pharmacological results showed that the target compounds bearing methoxy grou...

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Detalles Bibliográficos
Autores principales: Zhao, Xuan, Fang, Jiqing, Jia, Yu, Wu, Zi, Zhang, Meihui, Xia, Mingyu, Dong, Jinhua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9181915/
https://www.ncbi.nlm.nih.gov/pubmed/35684477
http://dx.doi.org/10.3390/molecules27113537

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9181915/
https://www.ncbi.nlm.nih.gov/pubmed/35684477
http://dx.doi.org/10.3390/molecules27113537

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