Cargando…

Synthesis and Anti-Neuroinflammatory Activity of 1,7-diphenyl-1,4-heptadien-3-ones in LPS-Stimulated BV2 Microglia Via Inhibiting NF-κB/MAPK Signaling Pathways

A series of 1,7-diphenyl-1,4-heptadien-3-ones with various substituents (HO-, CH(3)O-, CH(3)-, Cl-) on the phenyl rings were synthesized and evaluated for anti-neuroinflammatory effects in LPS-stimulated BV2 microglia. The pharmacological results showed that the target compounds bearing methoxy grou...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zhao, Xuan, Fang, Jiqing, Jia, Yu, Wu, Zi, Zhang, Meihui, Xia, Mingyu, Dong, Jinhua
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9181915/ https://www.ncbi.nlm.nih.gov/pubmed/35684477 http://dx.doi.org/10.3390/molecules27113537

Ejemplares similares

Nordalbergin Exerts Anti-Neuroinflammatory Effects by Attenuating MAPK Signaling Pathway, NLRP3 Inflammasome Activation and ROS Production in LPS-Stimulated BV2 Microglia
por: Lo, Jung, et al.
Publicado: (2023)

Anti-neuroinflammatory Activity of Elephantopus scaber L. via Activation of Nrf2/HO-1 Signaling and Inhibition of p38 MAPK Pathway in LPS-Induced Microglia BV-2 Cells
por: Chan, Chim-Kei, et al.
Publicado: (2017)

Atractylodis Rhizoma Alba Attenuates Neuroinflammation in BV2 Microglia upon LPS Stimulation by Inducing HO-1 Activity and Inhibiting NF-κB and MAPK
por: Jeong, Yun Hee, et al.
Publicado: (2019)

Tabersonine Inhibits the Lipopolysaccharide-Induced Neuroinflammatory Response in BV2 Microglia Cells via the NF-κB Signaling Pathway
por: Shi, Jiaotai, et al.
Publicado: (2022)

Baicalin Mitigates the Neuroinflammation through the TLR4/MyD88/NF-κB and MAPK Pathways in LPS-Stimulated BV-2 Microglia
por: Li, Baojing, et al.
Publicado: (2022)

Angelicae Gigantis Radix Regulates LPS-Induced Neuroinflammation in BV2 Microglia by Inhibiting NF-κB and MAPK Activity and Inducing Nrf-2 Activity
por: Oh, You-Chang, et al.
Publicado: (2019)

Anti-Neuroinflammatory Effects and Mechanism of Action of Fructus ligustri lucidi Extract in BV2 Microglia
por: Kim, Yeon Ju, et al.
Publicado: (2021)

Benfotiamine Attenuates Inflammatory Response in LPS Stimulated BV-2 Microglia
por: Bozic, Iva, et al.
Publicado: (2015)

LPS and palmitic acid Co-upregulate microglia activation and neuroinflammatory response
por: Lu, Zhongyang, et al.
Publicado: (2021)

Ibrutinib suppresses LPS-induced neuroinflammatory responses in BV2 microglial cells and wild-type mice
por: Nam, Hye Yeon, et al.
Publicado: (2018)

Fucoxanthinol from the Diatom Nitzschia Laevis Ameliorates Neuroinflammatory Responses in Lipopolysaccharide-Stimulated BV-2 Microglia
por: Li, Yuelian, et al.
Publicado: (2020)

Minocycline and antipsychotics inhibit inflammatory responses in BV-2 microglia activated by LPS via regulating the MAPKs/ JAK-STAT signaling pathway
por: Long, Yujun, et al.
Publicado: (2023)

Synthetic 3′,4′-Dihydroxyflavone Exerts Anti-Neuroinflammatory Effects in BV2 Microglia and a Mouse Model
por: Kim, Namkwon, et al.
Publicado: (2018)

The Anti-Neuroinflammatory Effect of Fuzi and Ganjiang Extraction on LPS-Induced BV2 Microglia and Its Intervention Function on Depression-Like Behavior of Cancer-Related Fatigue Model Mice
por: Yang, Songwei, et al.
Publicado: (2021)

Anti-Neuroinflammatory Effect of the Ethanolic Extract of Black Ginseng through TLR4-MyD88-Regulated Inhibition of NF-κB and MAPK Signaling Pathways in LPS-Induced BV2 Microglial Cells
por: Kim, Kwan-Woo, et al.
Publicado: (2023)

The Anti-neuroinflammatory Activity of Tectorigenin Pretreatment via Downregulated NF-κB and ERK/JNK Pathways in BV-2 Microglial and Microglia Inactivation in Mice With Lipopolysaccharide
por: Lim, Hye-Sun, et al.
Publicado: (2018)

Salidroside Reduces Cell Mobility via NF-κB and MAPK Signaling in LPS-Induced BV2 Microglial Cells
por: Hu, Haixia, et al.
Publicado: (2014)

2-cyclohexylamino-5,8-dimethoxy-1,4-naphthoquinone inhibits LPS-induced BV2 microglial activation through MAPK/NF-kB signaling pathways
por: Sun, Hu-Nan, et al.
Publicado: (2016)

Blueberry Counteracts BV-2 Microglia Morphological and Functional Switch after LPS Challenge
por: De Caris, Maria Giovanna, et al.
Publicado: (2020)

Response Profiles of BV2 Microglia to IFN-γ and LPS Co-Stimulation and Priming
por: Pan, Meng Liy, et al.
Publicado: (2023)

Diastereoselective Carbocyclization of 1,6-Heptadienes Triggered by Rhodium-Catalyzed Activation of an Olefinic C=H Bond**
por: Aïssa, Christophe, et al.
Publicado: (2014)

Thromboxane A2 receptor antagonist SQ29548 suppresses the LPS-induced release of inflammatory cytokines in BV2 microglia cells via suppressing MAPK and NF-κB signaling pathways
por: Yan, Aijuan, et al.
Publicado: (2017)

Caspase-1 inhibition attenuates activation of BV2 microglia induced by LPS-treated RAW264.7 macrophages
por: Pan, Yang, et al.
Publicado: (2016)

Tetrathiomolybdate Treatment Leads to the Suppression of Inflammatory Responses through the TRAF6/NFκB Pathway in LPS-Stimulated BV-2 Microglia
por: Wang, Zhuo, et al.
Publicado: (2018)

CLG from Hemp Seed Inhibits LPS-Stimulated Neuroinflammation in BV2 Microglia by Regulating NF-κB and Nrf-2 Pathways
por: Wang, Shanshan, et al.
Publicado: (2019)

Amentoflavone Exerts Anti-Neuroinflammatory Effects by Inhibiting TLR4/MyD88/NF-κB and Activating Nrf2/HO-1 Pathway in Lipopolysaccharide-Induced BV2 Microglia
por: Rong, Shikuo, et al.
Publicado: (2022)

Anti-neuroinflammatory effects of Cleistocalyx nervosum var. paniala berry-seed extract in BV-2 microglial cells via inhibition of MAPKs/NF-κB signaling pathway
por: Janpaijit, Sakawrat, et al.
Publicado: (2022)

Sinapic Acid Attenuates the Neuroinflammatory Response by Targeting AKT and MAPK in LPS-Activated Microglial Models
por: Huang, Tianqi, et al.
Publicado: (2023)

Anti-neuroinflammatory Effects of 12-Dehydrogingerdione in LPS-Activated Microglia through Inhibiting Akt/IKK/NF-κB Pathway and Activating Nrf-2/HO-1 Pathway
por: Zhao, Dong, et al.
Publicado: (2019)

Taraxasterol Inhibits LPS-Induced Inflammatory Response in BV2 Microglia Cells by Activating LXRα
por: Liu, Bin, et al.
Publicado: (2018)

6-Shogaol attenuates LPS-induced inflammation in BV2 microglia cells by activating PPAR-γ
por: Han, Qinghe, et al.
Publicado: (2017)

Rhein Suppresses Neuroinflammation via Multiple Signaling Pathways in LPS-Stimulated BV2 Microglia Cells
por: Zheng, Piao, et al.
Publicado: (2020)

TSPO Ligands Protect against Neuronal Damage Mediated by LPS-Induced BV-2 Microglia Activation
por: Ma, Baoyu, et al.
Publicado: (2022)

Malonic acid suppresses lipopolysaccharide-induced BV2 microglia cell activation by inhibiting the p38 MAPK/NF-κB pathway
por: Lee, Hana, et al.
Publicado: (2021)

Quantitative Analysis of Psoralea corylifolia Linne and its Neuroprotective and Anti-Neuroinflammatory Effects in HT22 Hippocampal Cells and BV-2 Microglia
por: Kim, Yu Jin, et al.
Publicado: (2016)

Astragalin and Isoquercitrin Isolated from Aster scaber Suppress LPS-Induced Neuroinflammatory Responses in Microglia and Mice
por: Kim, Eun Hae, et al.
Publicado: (2022)

Transcriptome sequencing reveals that LPS-triggered transcriptional responses in established microglia BV2 cell lines are poorly representative of primary microglia
por: Das, Amitabh, et al.
Publicado: (2016)

Anti-Inflammatory and Anti-Migratory Activities of Isoquinoline-1-Carboxamide Derivatives in LPS-Treated BV2 Microglial Cells via Inhibition of MAPKs/NF-κB Pathway
por: Do, Ha Thi Thu, et al.
Publicado: (2020)

Quercus acuta Thunb. Suppresses LPS-Induced Neuroinflammation in BV2 Microglial Cells via Regulating MAPK/NF-κB and Nrf2/HO-1 Pathway
por: Kim, Jae Kwang, et al.
Publicado: (2022)

Anti-Neuroinflammatory and Neuroprotective Effect of Intermedin B Isolated from the Curcuma longa L. via NF-κB and ROS Inhibition in BV2 Microglia and HT22 Hippocampal Cells
por: Lee, Hwan, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_k3r5phbu18uci0ur0ba3068ioa